Peptides for inhibiting pepsin release
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorsMonique Descroix-Vagne, Danielle Pansu, Thierry Tarrade
Life of this patent
Estimating the term…
Abstract
Peptides derived from the C terminal sequence of sorbin, but containing at least one D-amino acid residue, inhibit pepsin release and are therefore likely to be useful in the treatment of ulcers or oesophagitis. Their salts and substitution derivatives are also claimed as a pharmaceutical compositions containing them. A method for the treatment of a patient suffering from gastric ulcers or oesophagitis comprising the administration of said peptides, is also claimed.
Claims25
A peptide of the general formula I
- A.sub.1 --A.sub.2 --A.sub.3 --X I
- in which:
- A.sub.1 represents the residue L-Thr or D-Thr;
- or one of the following sequences in which at least one amino acid residue may be of D configuration:
- Val-Thr,
- Pro-Val-Thr,
- Arg-Pro-Val-Thr,
- Glu-Arg-Pro-Val-Thr,
- His-Glu-Arg-Pro-Val-Thr,
- Gln-His-Glu-Arg-Pro-Val-Thr,
- Leu-Gln-His-Glu-Arg-Pro-Val-Thr,
- Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr,
- Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr,
- Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr,
- Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr,
- Gly-Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr,
- Pro-Gly-Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr or
- Glu-Pro-Gly-Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr;
- A.sub.2 represents the sequence Lys-Pro-Gln-Ala in which at least one amino acid residue may be of D configuration;
- A.sub.3 represents a covalent bond or the sequence Gly-A.sub.4 -A.sub.5 in which each of A.sub.4 and A.sub.5 independently represents a basic amino acid residue;
- and
- X represents a hydroxy, amino or alkylamino group;
- with the proviso that the peptide contains at least one D-amino acid residue.
A peptide of the formula Thr-Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula Thr-Lys-Pro-Gln-D-Ala-Gly-Lys-Lys-NH.sub.2.
A peptide of the formula Thr-(acetyl)Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula Pro-Val-Thr-Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula Pro-D-Val-Thr-Lys-Pro-Gln-Ala-NH2.
A peptide of the formula Pro-Val-Thr-Lys-Pro-Gln-Ala-Gly-Arg-D-Arg.
A peptide of the formula Pro-Val-Thr-(acetyl)Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula D-Pro-Val-Thr-Lys-Pro-Gln-Ala-NH.sub.2.
A peptide of the formula His-Glu-Arg-Pro-Val-Thr-Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr-Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula Glu-Pro-Gly-Lys-Ser-Ser-Ile-Leu-Gln-His-Glu-Arg-Pro-Val-Thr-Lys-Pro-Gln-D- Ala-NH.sub.2.
A peptide of the formula D-Pro-Val-Thr-Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula D-Pro-Val-Thr-Lys-Pro-Gln-Ala-Gly-D-Lys-Lys-NH.sub.2.
A peptide of the formula Pro-D-Val-Thr-Lys-Pro-Gln-D-Ala-NH.sub.2.
A peptide of the formula D-Pro-Val-Thr-(acetyl)Lys-Pro-Gln-D-Ala-NH.sub.2.
Dependencies are inferred from the claim text.