Compositions and methods for inhibiting elastase
AssigneeThe UAB Research Foundation
InventorEdward J. Miller
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Abstract
This invention provides a compound comprising: (1) a polypeptide moiety having a) an identifying number of amino acids for SPAAT, b) an elastase binding activity; and (2) an extracellular matrix protein bound to the polypeptide moiety. Also provided is a method of inhibiting an elastase comprising contacting the elastase with a polypeptide moiety having: (1) an identifying number of amino acids for SPAAT; (2) a collagen binding activity; and (3) elastase binding activity.
Claims16
A compound comprising:
- (a) an isolated polypeptide moiety having
- (i) an amino acid sequence shown in SEQ ID NO:4,
- (ii) an elastase binding activity;
- and
- (b) an extracellular matrix protein bound to the polypeptide moiety.
A kit comprising:
- (a) an isolated polypeptide moiety having
- (i) an amino acid sequence shown in SEQ ID NO:4,
- (ii) an elastase binding activity;
- and
- (b) an extracellular matrix protein.
A compound consisting of an isolated amino acid sequence of SEQ ID NO:4 bound by an extracellular matrix protein capable of binding the sequence.
A compound consisting of an isolated amino acid sequence shown in SEQ ID NO:4 which is recombinantly or synthetically produced and which has an elastase binding activity.
Dependencies are inferred from the claim text.