Nucleic acid encoding monoclonal antibodies to leukemia inhibitory factor
AssigneeGenentech, Inc.
InventorKyung Jin Kim
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Abstract
The invention relates to nucelic acids encoding monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or contributes to undesirable pathological effects, such as cachexia, dysregulated calcium metabolism, or excessive bone cell proliferation, and in the detection of hLIF, for example, in clinical samples or specimens.
Claims16
An isolated nucleic acid encoding an anti-human Leukemia Inhibitory Factor monoclonal antibody capable of being competitively inhibited in its binding to human Leukemia Inhibitory Factor by a monoclonal antibody selected from the group consisting of mAb D3.14.1, mAb D4.16.9, mAb D25.1.4, and mAb D62.3.2 (American Type Culture Collection Accession Numbers ATCC HB 11076, ATCC HB 11077, ATCC HB 11074 and ATCC HB 11075, respectively).
Dependencies are inferred from the claim text.