DNA and polypeptide for tumor-associated antigen CO-029
AssigneeThe Wistar Institute
InventorsAlban J. Linnenbach, Hilary Koprowski, Stanislaw Szala
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Abstract
The human tumor-associated antigen CO-029 is a monoclonal antibody-defined, 27-34 kDa cell surface glycoprotein. A full-length cDNA clone for CO-029 is described. When transiently expressed in COS cells, the cDNA clone directs the synthesis of an antigen reactive with monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis reveals that CO-029 belongs to a family of cell surface antigens which includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni.
Claims20
An intron-free DNA molecule which encodes a tumor-associated antigen, said antigen immunoreactive with monoclonal antibody CO-029.
The intron-free DNA molecule of claim i which is covalently linked to a vector which can replicate in E. coli.
An intron-free DNA molecule comprising a nucleic acid sequence shown in FIG. 3.
An intron-free DNA molecule which hybridizes under stringent conditions to DNA having the sequence shown in FIG. 3.
An intron-free DNA molecule which codes for a polypeptide consisting essentially of an extracellular domain of the CO-029 antigen.
A polypeptide consisting essentially of an extracellular domain of the CO-029 antigen.
A preparation of CO-029 antigen which is entirely free of other human proteins.
Non-human cells transformed with a DNA molecule encoding CO-029 antigen.
Dependencies are inferred from the claim text.