Antibody to the neural cell adhesion molecule and methods of use
AssigneeBecton, Dickinson and Company
InventorsDuane David Bronson, John Jacob Hemperly
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Abstract
The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in in vitro studies and for improving nerve regeneration and repair in vivo.
Claims3
A method for detecting N-CAM comprising contacting a cell or a cell extract containing N-CAM with monoclonal antibody NCAM16.2 and detecting the presence of the N-CAM by detecting binding of the monoclonal antibody NCAM16.2 to the N-CAM.
Dependencies are inferred from the claim text.