Pyruvate thiolester for the prevention of reperfusion injury
AssigneeCase Western Reserve University
InventorsHenri Brunengraber, Hermann Dugas, Khadija Quinze, Catherine Bomont
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Abstract
The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia. The novel pyruvate compound is particularly a pyruvate thiolester. Preferably, the thiol is selected from a cysteine or a methionine amino acid. In a particularly preferred form, the compound is an N-acetyl ethyl ester of the cysteine or methionine amino acid. The most preferred compound is: ##STR1##
Claims14
A process for preserving tissue deprived of oxygen comprising the step of treating said tissue with an effective amount of a pyruvate thiolester.
Dependencies are inferred from the claim text.