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US 5,667,806 AGranted
Spray drying method and apparatus
AssigneeEmisphere Technologies, Inc.
InventorMartin L. Kantor
Life of this patent
Estimating the term…
Abstract
Methods for preparing microspheres are provided. A carrier vehicle and a precipitator are nebulized and contacted. Alternatively, a carrier is nebulized in an aqueous acid and the concentration of the acid is decreased. Apparatus are also provided.
Claims38
A method for preparing microspheres, said method comprising:
- (A) nebulizing each of
- (a) a carrier vehicle comprising a microsphere forming carrier;
- and
- (b) a precipitator;
- wherein said carrier vehicle (a) or said precipitator (b) optionally includes an active agent;
- and
- (B) contacting said carrier vehicle and said precipitator.
4 more elements
A method for preparing microspheres, said method comprising:
- (A) nebulizing an aqueous acid/carrier solution comprising
- (a) a volatile acid;
- (b) a microsphere forming carrier;
- and
- (c) optionally an active agent;
- wherein the volume:volume ratio of acid to water in said carrier solution is at least about 3:7;
- and
- (B) decreasing said ratio to less than about 3:7, to yield said microspheres.
5 more elements
A method for preparing active agent containing microspheres, said method comprising:
- (A) nebulizing an aqueous acid/carrier solution comprising
- (a) a volatile acid;
- (b) a carrier comprising a member selected from the group consisting of
- (i) a proteinoid,
- (ii) an acylated amino acid or poly amino acid or a salt thereof,
- (iii) a sulfonated amino acid or poly amino acid or a salt thereof,
- (iv) a protein or a salt thereof,
- (v) an enteric coating material, and
- (vi) any combination thereof, and
- (c) an active agent;
- wherein the volume:volume ratio of acid to water in said carrier solution is at least about 3:7;
- and
- (B) decreasing said ratio to less than about 3:7, to yield said microspheres.
10 more elements
A method for preparing active agent containing microspheres, said method comprising
- (A) providing a spray nozzle comprising;
- (a) a first delivery pipe having an inlet portion and an outlet portion, said first pipe outlet portion in open communication with a nozzle outlet;
- (b) a second delivery pipe, said second pipe having an inlet and an outlet portion, said second pipe outlet portion in open communication with said nozzle outlet;
- and
- (c) a pressurized gas delivery jacket having an inlet portion and an outlet portion, said jacket outlet portion surrounding both said first and said second pipe outlet portions but not said nozzle outlet, and in open communication with said nozzle outlet;
- (B) delivering to said first delivery pipe inlet portion, a carrier vehicle comprising a carrier selected from the group consisting of
- (a) a proteinoid,
- (b) an acylated amino acid or poly amino acid or a salt thereof,
- (c) a sulfonated amino acid or poly amino acid or a salt thereof,
- (d) a protein or a salt thereof,
- (e) an enteric coating material, and
- (f) any combination thereof;
- (C) delivering a precipitator to said second delivery pipe inlet portion;
- (D) delivering pressurized air to said jacket;
- and
- (E) simultaneously nebulizing and contacting said carrier vehicle and said precipitator;
- wherein said carrier vehicle or said precipitator includes said active agent.
14 more elements
Dependencies are inferred from the claim text.