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AssigneeOy Polymer Corex Kuopio Ltd.
InventorsTimo Petteri Paronen, Soili Hellevi Peltonen, Arto Olavi Urtti, Leena Johanna Nakari
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The present invention is related to a novel type of composition with modifiable properties and suitable for controlled release of active ingredients in industrial use. The composition contains an active ingredient and starch acetate in the form of a compact. More specifically the invention relates to active ingredients such as solid dosage forms of drugs, especially compacts and tablets. In these compacts starch acetate with distinct substitution degrees are used. The starch acetate makes the process industrially feasible with good flowability and facilitates the formation of firm tablets. Starch acetate enables the controlled release of the active ingredient. The invention also discloses method for the preparation of the composition as well as its use.
A composition with modifiable excipient properties, comprising a compact, which in addition to at least one active ingredient comprises starch acetate, wherein the excipient properties of said composition are modifiable to be compatible with the intended excipient purpose by varying the substitution degree of starch acetate between 0.2-3.0, preferably 0.7-3.0 or/and changing the compressional force used in the manufacturing of the compact respectively.
A method for the preparation of a composition with modifiable properties, comprising the steps of mixing at least one active ingredient with starch acetate, the substitution degree of which is about 0.2-3.0 and compressing said mixture with such a force that a compact with properties compatible with the intended use are obtained.
A composition with modifiable excipient properties, comprising at least one active ingredient and an excipient consisting essentially of starch acetate having a substitution degree of starch between 0.2 and 3.0.
Dependencies are inferred from the claim text.