Anti-viral composition and kit and use for treating rotavirus infection and diarrhea

A method of retarding or treating rotavirus infection in a subject, comprising administering to the subject a composition comprising an anti-rotavirus effective amount of an agent selected from the group consisting of defatted human milk fat globule, the human milk macromolecular fraction, the human milk mucin-70 Kd apparent MW glycoprotein-46 Kd apparent MW glycoprotein complex, the 46 Kd apparent MW glycoprotein, a polypeptide comprising an amino acid sequence having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, deglycosylated proteins thereof, mixtures thereof, and mixtures thereof with human skim milk, curd, or whey.

A method of retarding or treating diarrhea associated with rotavirus infection in a subject comprising administering to the subject a composition comprising anti-diarrhea effective amount of an agent selected from the group consisting of defatted human milk fat globule, the human milk macromolecular fraction, the human milk mucin-70 Kd apparent MW HMFG glycoprotein-46 Kd apparent MW HMFG glycoprotein complex, the 46 Kd apparent MW HMFG glycoprotein, a polypeptide comprising an amino acid sequence having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, deglycosylated proteins thereof, mixtures thereof, and mixtures thereof with human skim milk, curd, or whey.

A method of retarding or treating infantile gastroenteritis associated with rotavirus infection comprising administering to an infant in need of the treatment a composition comprising an anti-infantile gastroenteritis effective amount of an agent selected from the group consisting of defatted human milk fat globule, the human milk macromolecular fraction, the human milk mucin-70 Kd apparent MW glycoprotein-46 Kd apparent MW glycoprotein complex, the 46 Kd apparent MW glycoprotein, a polypeptide comprising an amino acid sequence having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, deglycosylated products thereof, mixtures thereof, and mixtures thereof with human skim milk, curd, or whey.

A method of retarding or treating diarrhea associated with rotavirus infection comprising administering to a subject in need of the treatment a composition comprising an anti-diarrhea effective amount of an agent selected from the group consisting of defatted human milk fat globule, the human milk macromolecular fraction, the human milk mucin-70 Kd apparent MW glycoprotein-46 Kd apparent MW glycoprotein complex, the 46 Kd apparent MW glycoprotein, a polypeptide comprising in amino acid sequence having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, deglycosylated products thereof, mixtures thereof, and mixtures thereof with human skim milk, curd, or whey.

A method of retarding or treating diarrhea associated with rotavirus infection in an immunodeficient subject comprising administering to an immunodeficient subject in need of the treatment a composition comprising an anti-diarrhea effective amount of an agent selected from the group consisting of defatted human milk fat globule, the human milk macromolecular fraction, the human milk mucin-70 Kd apparent MW glycoprotein-46 Kd apparent MW glycoprotein complex, the 46 Kd apparent MW glycoprotein, a polypeptide comprising an amino acid sequence having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, deglycosylated products thereof, mixtures thereof, and mixtures thereof with human skim milk, curd, or whey.