Tocols as adjuvant in vaccine
AssigneeAkzo Nobel N.V.
InventorsLammert Cornelius, Eric Onno Rijke
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Abstract
Oil based vaccines often cause serious local side effects at the site of administration and/or have a high viscosity which make said vaccines difficult to handle. Vaccines comprising as an adjuvant a stable emulsion of tocols in water do not display these undesired effects and induce good immune responses.
Claims9
A method for immunizing an animal against a particular pathogen, comprising administering to said animal a vaccine comprising an immunogenic amount of antigen of said particular pathogen in an essentially mineral oil-free, stable oil-in-water emulsion comprising tocols, wherein the vaccine contains from 0.1 to 40% by weight tocols and the tocols have the formula:
- ##STR4## wherein:
- R may be H or one or more of identical or different substituents chosen from the group consisting of alkyl, alkoxy, acyloxy, hydroxy, a sulphate and a phosphate group;
- R.sub.1 and R.sub.3 independently of one another are H or alkyl;
- R.sub.2 is H or alkyl and may be different in each unit;
- the broken line indicates the presence or absence of an additional carbon-carbon bond in a unit;
- and
- n has the value 1 to 10.
Dependencies are inferred from the claim text.