Multiple particulate antigen delivery system
AssigneeOxford University
InventorPolly Roy
Life of this patent
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Abstract
Antigens in particulate form are provided wherein chimeric antigens having foreign epitopes are presented on or within virus-like particles (VLPs) or virus core-like particles (CLPs). The VLPs and CLPs are immunogenic and are useful in producing vaccine formulations.
Claims18
A particulate antigen in the form of a virus-like particle (VLP) or core-like particle (CLP) comprising bluetongue virus VP3 protein and a chimeric VP7 protein, wherein the chimeric VP7 protein comprises a foreign epitope fused to the N-terminus of bluetongue virus VP7.
A particulate antigen in the form of a virus-like particle (VLP) or core-like particle (CLP) comprising bluetongue virus VP3 and VP7 proteins and a chimeric VP6 protein, wherein the chimeric VP6 protein comprises a foreign epitope fused to the C-terminus of bluetongue virus VP6.
A method of making a chimetic VLP or CLP, comprising assembling a VLP or CLP comprising bluetongue virus VP3 protein and a chimeric VP7 protein, wherein the chimeric VP7 protein comprises a foreign epitope fused to the N-terminus of bluetongue virus VP7.
A method of making a chimeric VLP or CLP, comprising assembling a VLP or CLP comprising bluetongue virus VP3 and VP7 proteins and a chimeric VP6 protein, wherein the chimeric VP6 protein comprises a foreign epitope, fused to the C-terminus of bluetongue virus VP6.
Dependencies are inferred from the claim text.