Antibodies to SMDF
AssigneeGenentech, Inc.
InventorsWei-Hsien Ho, Phyllis L. Osheroff
Life of this patent
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Abstract
Isolated SMDF, isolated DNA encoding SMDF, and antibodies to SMDF are disclosed. SMDF contains a .beta.-type EGF-like domain and a N-terminal sequence which is distinct from all neuregulins reported so far. SMDF, when expressed in recombinant cell culture, activates tyrosine phosphorylation of the HER2/neu receptor in human breast cancer cells and displays mitogenic activity on Schwann cells. Northern blot and in situ hybridization analysis show that SMDF differs from other neuregulins in that it is nervous tissue specific, and is very highly expressed, in comparison to other neuregulins, in the human and rat spinal cord motor neurons and sensory neurons.
Claims12
An isolated antibody that binds to the N-terminal domain of sensory and motor neuron derived factor (SMDF), wherein the SMDF is human SMDF as in SEQ ID NO:
- 2 or SMDF having the amino acid sequence of a native SMDF from a nonhuman mammal.
An isolated antibody that binds to the N-terminal domain of sensory and motor neuron derived factor (SMDF) in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.