Treatment for biological damage using tumor necrosis factor and a free-radical scavenger
AssigneeChiron Corporation
InventorsRobert Zimmerman, Benedict J. Marafino, Jr.
Life of this patent
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Abstract
Damage to cells, tissue and other body parts in a mammalian host may be treated by using a tumor necrosis factor in conjunction with at least one biological modifier, which may be a free radical scavenger or a metabolic inhibitor. The biological modifier is preferably uric acid, buthionine sulphoximine, vitamin C, aspirin, or nordihydroguaiaretic acid. Such a combination may be used to treat, for example, cancer, infectious diseases, and damage caused by radiation therapy, high oxygen tension, and chemotherapy.
Claims30
A method for the therapeutic or prophylactic treatment of biological damage to a mammalian host, said damage caused by free radical generation, which method comprises administering to the host in need of such treatment a therapeutically effective amount of a tumor necrosis factor from a mammalian species and a therapeutically effective amount of at least one free radical scavenger.
A composition comprising therapeutically effective amount of a tumor necrosis factor from a mammalian species and a therapeutically effective amount of a free radical scavenger.
A method for treating biological damage in a host in need of such treatment, wherein said damage is caused by free radical generation, which method comprises:
- administering to the host a therapeutically effective amount of a free radical scavenger in a first pharmaceutically acceptable carrier, and
- administering to the host a therapeutically effective amount of a tumor necrosis factor in a second pharmaceutically acceptable carrier.
A unit dose comprising a first composition having a therapeutically effective amount of a tumor necrosis factor from a mammalian species, and further comprising a second composition having a therapeutically effective amount of a free radical scavenger.
A kit comprising a therapeutically effective amount of a tumor necrosis factor from a mammalian species in association with a therapeutically effective amount of a free radical scavenger, said kit facilitating separate administration to a host of said therapeutically effective amount of a tumor necrosis factor from a mammalian species and said therapeutically effective amount of a free radical scavenger.
Dependencies are inferred from the claim text.