Use and composition of an anti-sexually transmitted diseases formulation
AssigneeColumbia Laboratories, Inc.
InventorsWilliam J. Bologna, Howard L. Levine
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Abstract
The present invention provides a composition and use of a composition comprising a bioadhesive cross-linked polycarboxylic acid polymer formulation that enables the use of relatively low mounts of anti-STD infectants, such as N-9, to be used to prevent infection by STDs without causing the irritation to genital tissue that often accompanies higher doses of anti-STDs. The bioadhesive polymer maintains greater contact between the anti-STD agent and the infectant for a much greater period of time, enabling a lower concentration to act longer on the infectant, when compared to currently-available commercial applications containing N-9. Such delivery will enable a safe and non-irritating decrease in the risk of infection with STDs, including HIV.
Claims8
A method of delivering N-9 as an anti-HIV agent to a female subject comprising inserting a bioadhesive cross-linked polycarboxylic acid polymer formulation with N-9 into the vagina, wherein the formulation releases N-9 at a rate sufficient to demonstrate anti-HIV activity for at least about twenty-four hours without significant causation of irritation to the local epithelial tissue.
A method of delivering N-9 as an anti-HIV agent to a female subject comprising inserting a bioadhesive cross-linked polycarboxylic acid polymer formulation with N-9 into the vagina, wherein the formulation releases N-9 in an amount sufficient to demonstrate anti-HIV activity for at least about twenty-four hours without significant causation of irritation to the local epithelial tissue.
Dependencies are inferred from the claim text.