Amphiphilic derivatives of piperazine
AssigneeMegabios Corporation
InventorsTimothy D. Heath, Igor Solodin
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Abstract
Novel, heterocyclic cationic amphiphile and compounds thereof are prepared that are degraded in vivo. Liposomes are produced from the cations that are used as carriers for delivering macromolecules intracellularly and may be targeted to a specific cell type.
Claims30
A heterocyclic, amphiphilic cation of the formula ##STR6## wherein each R independently is a straight-chain, aliphatic hydrocarbyl group of from 5 to 29 carbon atoms inclusive, each Y is --CH.sub.2 -- or --CO--, each R' independently is a lower alkyl, each m independently is an integer from 0 to 7 inclusive and n is zero or 1, with the proviso that the total number of carbon atoms in R and --(CH.sub.2).sub.m -- is at least 10.
A compound of the formula ##STR7## wherein each R independently is a straight-chain, aliphatic hydrocarbyl group of from 5 to 29 carbon atoms inclusive, each Y is --CH.sub.2 -- or --CO--, each R' independently is a lower alkyl, each m independently is an integer from 0 to 7 inclusive, n is zero or 1 and X is one or more anions having a total oxidation state of -(l+n), with the proviso that the total number of carbon atoms in R and --(CH.sub.2).sub.m -- is at least 10.
Dependencies are inferred from the claim text.