Glucocorticoid response elements
AssigneeDana-Farber Cancer Institute, Inc.
InventorsPriscilla A. Schaffer, Mary Ann Hardwicke
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Abstract
The invention features an isolated herpesvirus glucocorticoid response element comprising a DNA sequence comprising two consensus hexanucleotide glucocorticoid receptor binding sequences having at least five nucleotides positioned therebetween. The invention further features compositions and methods for preventing herpesvirus replication and reactivation.
Claims20
An herpesvirus glucocorticoid response element having the sequence 5'-TGTCCT (N).sub.x AGGACA -3', wherein x is five to twenty nucleotides [SEQ ID NO:48.
The herpesvirus glucocorticoid response element having the sequence 5'-AGGACA (N).sub.x TGTCCT -3', wherein x is five to twenty nucleotides [SEQ ID NO:66.
An isolated nucleic acid sequence of 18 to 100 nucleotides complementary to a DNA sequence comprising a herpesvirus glucocorticoid response element, said herpesvirus glucocorticoid response element comprising two consensus hexanucleotide glucocorticoid receptor binding sequences having at least five nucleotides positioned therebetween, wherein said hexanucleotide sequence comprises the sequences 5'-TGTCCT-3' and 5'-AGGACA3'.
A herpesvirus glucocorticoid response element having the sequence 5' TGTCCT (N).sub.18 AGGACA -3' [SEQ ID NO:2].
A herpesvirus glucocorticoid response element having the sequence 5'-AGGACA (N).sub.6 TGTCCT -3' [SEQ ID NO:3].
Dependencies are inferred from the claim text.