Molecules influencing the shedding of the TNF receptor, their preparation and their use
AssigneeYeda Research and Development Co. Ltd.
InventorsDavid Wallach, Cord Brakebusch, Eugene Varfolomeev, Michael Batkin
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Abstract
Molecules which influence the shedding of the cell-bound p55 Tumor Necrosis Factor receptor (p55-TNF-R), are provided, together with methods of producing them.
Claims18
A peptide consisting of a sequence comprising residues 202-211 of SEQ ID NO:2 except for the deletion of residue 202, the deletion of residues 202 and 203, the deletion of residues 203 and 204, the substitution of Pro at residues 202, 203 or 204, or the substitution of ASp or Gly at residue 202, said peptide having the property of being recognized by a protease capable of cleaving the soluble p55 TNF-R from cell-bound TNF-R, but inhibiting the proteolytic activity thereof.
Dependencies are inferred from the claim text.