Reversal of multi-drug resistance by tetraarylethylenes
AssigneeMerrell Pharmaceuticals Inc.
InventorSai Prasad Sunkara
Life of this patent
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Abstract
Certain tetraarylethylenes reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.
Claims10
A method of reversing multidrug resistance in a patient having a multidrug resistant tumor which comprises administering to said patient a multidrug resistance reversing amount of a compound of the formula ##STR3## wherein Ar is a group of the formula ##STR4## wherein Am is a di(C.sub.1-4 alkyl)substituted amino group, x is an integer of from 1 to 4 and R.sub.1, R.sub.2, and R.sub.3 are each independently selected from hydrogen and methoxy or an acid addition salt thereof.
A method for reversing vinblastine resistance in a patient having a vinblastine resistant tumor which comprises administering to said patient a vinblastine resistance reversing amount of a compound of the formula ##STR5## wherein Ar is a group of the formula ##STR6## wherein Am is a di(C.sub.1-4 alkyl)substituted amino group, x is an integer of from 1 to 4 and R.sub.1, R.sub.2, and R.sub.3 are each independently selected from hydrogen and methoxy or an acid addition salt thereof.
Dependencies are inferred from the claim text.