Platinum complexes
AssigneeJohnson Matthey Public Limited Company
InventorBarry A. Murrer
Life of this patent
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Abstract
Platinum complexes of formula Ia or Ib ##STR1## where each A, is a leaving group and may be the same or different, which is suitably halo, especially chloro, hydroxy, carboxylate or together form a bi-dentate carboxylate or sulphate, each B, which may be the same or different, is halo, hydroxy, carboxylate, carbamate or carbonate ester, Z is a substituted amine wherein the substituent sterically hinders access of the Pt atom to a DNA strand of a tumour cell, and X is NH.sub.3 or mono- or di-alkyl substituted NH.sub.3, are active against cancer cells, and appear to show a unique form of chemical and biological action.
Claims10
A cis-platinum complex of general formula Ia or Ib ##STR3## where each A, is a leaving group and may be the same or different, or together form a bi-dentate carboxylate or sulphate, each B, which may be the same or different, is halo, hydroxy, carboxylate, carbamate or carbonate ester,
- Z is a substituted amine wherein the substituent sterically hinders access of the Pt atom to a DNA strand of a tumour ceil, and
- X is NH.sub.3 or mono- or di-alkyl substituted NH.sub.3.
A cis-platinum complex selected from the group consisting of
- (SP-4-3)-amminedichloro(2-methylpyridine) platinum(II);
- (SP-4-3)-amminedichloro(2-ethylpyridine) platinum(II);
- (SP-4-3)-amminedichloro(2 -methyl-quinoline) platinum(II);
- (SP-4-3)-amminedichloro(2,4 -dimethylpyridine) platinum(II);
- (SP -4-3)-ammine-dichloro(2-isopropylpyridine ) platinum(II);
- (SP-4-3)-ammine-dichloro(2,6-dimethylpyridine) platinum(II);
- (OC-6-43)-amminedichlorodihydroxo-(2,4-dimethylpyridine) platinum(IV);
- (OC-6-43)-aminebisbutyratodichloro(2,4-dimethylpyridine) platinum(IV);
- and ammine(cyclobutane-1,1-dicarboxylato) (2,4-dimethylpyridine) platinum(II).
Dependencies are inferred from the claim text.