Method for treatment of cataract with radical scavenger
AssigneeGakko Hojin Kinki Daigaku
InventorsMotome Terao, Yoshimasa Ito
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Abstract
The invention provides a method for treatment of cataract which comprises administering to a subject in need of such treatment, a radical scavenger in an amount effective in treatment of cataract selected from the group consisting of a reducing thiol derivative, or a disulfide derivative and a sulfide derivative thereof, and a pharmaceutical composition for treatment of cataract which comprises an anti-cataract agent containing a radical scavenger and fine particles, such as emulsions, nanocapsules, alubmin microspheres and liposomes, which carries an anti-cataract agent and has a lipophilic and positively charged phase on the surface thereof.
Claims23
A pharmaceutical composition for treatment of cataract which comprises fine particles selected from the group consisting of emulsions, nanocapsules, albumin microspheres and liposomes, carrying an anti-cataract agent containing a radical scavenger comprising a disulfide derivative of formula:
- ##STR3## wherein R.sup.1 and R.sup.2 are independently a straight or branched lower alkyl which may be substituted by hydroxy, lower alkyloxy or lower alkyl carbonyloxy.
A pharmaceutical composition for treatment of cataract which comprises fine particles selected from the group consisting of emulsions, nanocapsules, albumin microspheres and liposomes, carrying an anti-cataract agent containing a radical scavenger comprising a reducing thiol derivative in which said reducing thiol is a compound of formula:
- ##STR4## wherein R.sup.1, R.sup.2 and R.sup.3 are independently a straight or branched lower alkyl which may be substituted by hydroxy, lower alkyloxy or lower alkyl carbonyloxy.
A pharmaceutical composition for treatment of ophthalmic disorders which comprises an agent for treatment of ophthalmic disorders, included in fine particles selected from the group consisting of emulsions, nanocapsules, albumin microspheres and liposomes, the surface of said fine particles having a lipophilic and positively charged phase.
A method for treatment of cataract which comprises administering to a subject in need of such treatment, a radical scavenger in an amount effective in treatment of cataract comprising a disulfide derivative of formula:
- ##STR5## wherein R.sup.1 and R.sup.2 are independently a straight or branched lower alkyl which may be substituted by hydroxy, lower alkyloxy or lower alkyl carbonyloxy.
A method for treatment of cataract which comprises administering to a subject in need of such treatment, a radical scavenger in an amount effective in treatment of cataract comprising a reducing thiol derivative in which said reducing thiol is a compound of formula:
- ##STR6## wherein R.sup.1 and R.sup.2 and R.sup.3 are independently a straight or branched lower alkyl which may be substituted by hydroxy, lower alkyloxy or lower alkyl carbonyloxy.
Dependencies are inferred from the claim text.