Ester of an organic nitrate and a salicylate
AssigneeCal International Limited
InventorsWilliam Byrne, Andrew Rynne
Life of this patent
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Abstract
A pharmaceutical product for the relief of the symptoms of angina pectoris and the like comprises an ester of an organic nitrate and a salicylate or derivative thereof having anti-platelet activity.
Claims25
A salicylate ester of an organic nitrate, wherein said organic nitrate is either directly or indirectly esterifiable and selected from the group consisting of isosorbide nitrate, glyceryl nitrate, pentaerythritol nitrate, Mannitol Hexanitrate, Trolnitrate Phosphate, Pentaerythritol Tetranitrate, Propatyl Nitrate, Clonitrate and Isosorbide Dinitrate.
Isosorbide 5-mononitrate-2-aspirinate.
A transdermal patch comprising isosorbide 5-mononitrate-2-aspirinate.
A soft capsule comprising isosorbide 5-mononitrate-2-aspirinate.
A method for the treatment of angina, comprising administering to a patient in need thereof, a pharmaceutical composition comprising an effective amount of a salicylate ester of an organic nitrate wherein said salicylate ester of an organic nitrate is selected from the group consisting of salicylate esters of isosorbide nitrate, glyceryl nitrate, pentaerythritol nitrate, Mannitol Hexanitrate, Trolnitrate Phosphate, Pentaerythritol Tetranitrate, Propatyl Nitrate, Clonitrate and Isosorbide Dinitrate.
Dependencies are inferred from the claim text.