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US 5,665,762 AGranted
Decontaminating clinical samples
AssigneeCarus Corporation
InventorsPeter G. Carroll, Stephen T. Isaacs, George D. Cimino
Life of this patent
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Abstract
The present invention contemplates methods of decontaminating human fluids prior to processing in the clinical laboratory. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.
Claims17
A method of pathogen inactivation, comprising:
- a) providing, in any order:
- i) an aminomethoxypsoralen;
- ii) psoralen activation means;
- iii) a biological fluid intended for in vitro testing suspected of being contaminated with one or more pathogens;
- b) adding said aminomethoxypsoralen to said biological fluid;
- and
- c) activating said aminomethoxypsoralen by said psoralen activation means, so that said activated aminomethoxypsoralen binds covalently to the nucleic acid of said pathogens.
4 more elements
A method of pathogen inactivation, comprising:
- a) providing, in any order, i) 4'-aminomethyl-4,5'-dimethyl-8-methoxypsoralen;
- ii) psoralen activation means;
- iii) a biological fluid intended for in vitro testing suspected of being contaminated with one or more pathogens;
- b) adding said 4'-aminomethyl-4,5'-dimethyl-8-methoxypsoralen to said fluid;
- and
- e) activating said 4'-aminomethyl-4,5'-dimethyl-8-methoxypsoralen by said psoralen activation means, so that said activated 4'-aminomethyl-4,5'-dimethyl-8-methoxypsoralen binds covalently to the nucleic acid of said pathogens.
3 more elements
Dependencies are inferred from the claim text.