Methods and compositions for protecting animals against attack and infestation by helminth, acarid and arthropod endo- and ectoparasites

A method for treating, controlling, preventing or protecting a warm-blooded animal from infestation or infection by helminths, acarids or arthropod endo- or ectoparasites which comprises administering or applying to said animal an anthelmintically, acaricidally or endo- or ectoparasiticidally effective amount of a pyrrole carbonitrile or nitropyrrole compound wherein the compound has the structure:

• ##STR51## wherein W is CN or NO.sub.2 ;
• X is CN, Br, Cl, I or CF.sub.3 ;
• Y is H, Br, Cl, I or CF.sub.3 ;
• Z is H, Br, Cl or I;
• and
• B is CR, ##STR52## hydrogen, C.sub.1 -C.sub.6 alkyl optionally substituted with one to three halogen atoms,
• one tri(C.sub.1 -C.sub.4 alkyl)silyl,
• one hydroxy,
• one cyano,
• one or two C.sub.1 -C.sub.4 alkoxy groups optionally substituted with one to three halogen atoms,
• one C.sub.1 -C.sub.4 alkylthio,
• one phenyl optionally substituted with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one phenoxy group optionally substituted with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one benzyloxy group optionally substituted on the phenyl ring with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one C.sub.1 -C.sub.6 alkylcarbonyloxy group optionally substituted with one to three halogen atoms,
• one C.sub.2 -C.sub.6 alkenylcarbonyloxy group optionally substituted with one to three halogen atoms,
• one phenylcarbonyloxy group optionally substituted with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one phenylcarbonyl group optionally substituted with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one C.sub.1 -C.sub.6 alkoxycarbonyl group optionally substituted with one to three halogen atoms or one to three C.sub.1 -C.sub.4 alkoxy groups, or
• one benzyloxycarbonyl group optionally substituted on the phenyl ring with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one C.sub.1 -C.sub.6 alkyloxycarbonyloxy group optionally substituted with one to three halogen atoms,
• C.sub.3 -C.sub.6 alkenyl optionally substituted with one to three halogen atoms or one phenol group,
• C.sub.3 -C.sub.6 alkynyl optionally substituted with one to three halogen atoms or one phenyl group,
• C.sub.1 -C.sub.6 alkyl substituted with one to three halogen atoms and one C.sub.1 -C.sub.4 alkoxy group,
• C.sub.3 -C.sub.6 1,2-alkadienyl, or cyano;
• R is
• C.sub.1 -C.sub.6 alkyl optionally substituted with one to three halogen atoms,
• one hydroxy,
• one cyano,
• one or two C.sub.1 -C.sub.4 alkoxy groups optionally substituted with one to three halogen atoms,
• one C.sub.1 -C.sub.4 alkylthio,
• one phenyl optionally substituted with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one phenoxy group optionally substituted with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one benzyloxy group optionally substituted on the phenyl ring with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one C.sub.1 -C.sub.6 alkylcarbonyloxy group optionally substituted with one to three halogen atoms,
• one C.sub.2 -C.sub.6 alkenylcarbonyloxy group optionally substituted with one to three halogen atoms,
• one phenylcarbonyloxy group optionally substituted with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• one C.sub.1 -C.sub.6 alkoxycarbonyl group optionally substituted with one to three halogen atoms or one to three C.sub.1 -C.sub.4 alkoxy groups, or
• one benzyloxycarbonyl group optionally substituted on the phenyl ring with one to three halogen atoms, one to three C.sub.1 -C.sub.4 alkyl groups or one to three C.sub.1 -C.sub.4 alkoxy groups,
• C.sub.3 -C.sub.6 alkenyl optionally substituted with one to three halogen atoms or one phenyl group,
• C.sub.3 -C.sub.6 alkynyl optionally substituted with one to three halogen atoms or one phenyl group,
• phenyl optionally substituted with one to three halogen atoms, one or two C.sub.1 -C.sub.4 alkyl groups, one or two C.sub.1 -C.sub.4 alkoxy groups, CF.sub.3, CN, NO.sub.2, di(C.sub.1 -C.sub.4 alkyl)amino or C.sub.1 -C.sub.4 alkanoylamino,
• phenoxy optionally substituted with one to three halogen atoms, one or two C.sub.1 -C.sub.4 alkyl groups, one or two C.sub.1 -C.sub.4 alkoxy groups, CF.sub.3, CN or NO.sub.2, di(C.sub.1 -C.sub.4 alkyl)amino or C.sub.1 -C.sub.4 alkanoylamino,
• C.sub.1 -C.sub.6 alkoxy optionally substituted with one to three halogen atoms,
• C.sub.2 -C.sub.6 alkenyloxy optionally substituted with one to three halogen atoms,
• di(C.sub.1 -C.sub.4 alkyl)amino,
• N-(C.sub.1 -C.sub.4 alkyl)-N-phenylamino or N-(C.sub.1 -C.sub.4 alkyl)-N-halophenylamino, or
• C.sub.3 -C.sub.6 polymethyleneimino.