Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis
AssigneePfizer Inc.
InventorJames Frederick Eggler
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Abstract
This invention relates to new heterocyclic compounds which are selective inhibitors of 5-lipoxygenase (5-LO). The new heterocyclic compounds are useful in inhibiting 5-LO per se and in the treatment or alleviation of inflammatory disease or condition, allergy or cardiovascular diseases in mammals wherein the inflammatory disease or condition includes but is not limited to asthma, arthritis, bronchi chronic obstructive pulmonary disease, psoriasis, allergic rhinitis, dermatitis, shock, atopic dermatitis, rheumatoid arthritis or osteoa This invention also relates to pharmaceutical compositions useful therefor.
Claims9
A compound of the formula ##STR5## wherein R.sup.1 is (C.sub.1 -C.sub.6)alkyl, (C.sub.3 -C.sub.10)cycloalkyl, (C.sub.3 -C.sub.6)alkenyl, (C.sub.3 -C.sub.6)alkynyl or (C.sub.1 -C.sub.6)alkyl-phenyl wherein the alkyl portion is optionally substituted by methyl or ethyl and the phenyl portion is optionally substituted by (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkyl, F, Cl, Br or CF.sub.3 ;
- R.sup.2 is hydrogen or fluoro;
- and
- R.sup.3 is hydrogen, methyl, ethyl, propyl, isopropyl, CF.sub.2 H or CF.sub.3.
Dependencies are inferred from the claim text.