Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them

A benzoylguanidine of the formula I ##STR18## R(1) is hydrogen, F, Cl, Br, I, --NO.sub.2, --C.tbd.N, R(16)--C.sub.p H.sub.2p --O.sub.q, R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 ---;

• is zero, 1, 2 or 3;
• q is zero or 1;
• R(16) is C.sub.r F.sub.2r+1 ;
• r is 1, 2 or 3,
• m is zero, 1 or 2;
• R(4) and R(5) independently of one another are (C.sub.1 -C.sub.8)-alkyl, (C.sub.3 -C.sub.6)-alkenyl, --C.sub.n H.sub.2n --R(7) or CF3;
• n is zero, 1, 2, 3 or 4
• R(7) is (C.sub.3 -C.sub.7)-cycloalkyl or phenyl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, methyl, methoxy and NR(8)R(9);
• R(8) and R(9) independently of one another are H or C.sub.1 -C.sub.4 -alkyl;
• or
• R(5) is H;
• R(6) H or (C.sub.1 -C.sub.4)-alkyl;
• or
• R(5) and R(6) are together 4 or 5 methylene groups, of which one CH.sub.2 group can be replaced by oxygen, S, NH, N--CH.sub.3 or N-benzyl;
• R(2) is (C.sub.1 -C.sub.9)-heteroaryl, which is linked via C or N and which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, CH.sub.3, methoxy, hydroxy, amino, methylamino and dimethylamino;
• or
• R(2) is --SR(10), --OR(10), --NR(10)R(11) or --CR(10)R(11)R(12);
• R(10) is --C.sub.a H.sub.2a --(C.sub.1 -C.sub.9)-heteroaryl, which is unsubstituted or substituted by 1-3substituents selected from the group consisting of F, Cl, CF.sub.3, CH.sub.3, methoxy, hydroxyl, amino, methylamino and dimethylamino;
• a is zero, 1 or 2;
• R(11) and R(12) independently of one another have the definition given R(10) or are hydrogen or (C.sub.1 -C.sub.4)-alkyl;
• R(3) has the definition given for R(1) or is (C.sub.1 -C.sub.6)-alkyl or --X--R(13);
• X is oxygen, S or NR(14);
• R(14) is H or (C.sub.1 -C.sub.3)-alkyl;
• R(13) is H, (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.8)-cycloalkyl:or --C.sub.b H.sub.2b --R(15);
• b is zero, 1, 2, 3 or 4;
• R(15) is phenyl which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, methyl, methoxy and NR(8)R(9);
• R(8) and R(9) independently of one another are H or (C.sub.1 -C.sub.4)-alkyl;
• with the exception of compounds I in which R(1) is R(4)-SO.sub.m or R(5)NSO.sub.2 and R(2) simultaneously is (C.sub.1 -C.sub.9)-heteroaryl,
• and the pharmaceutically acceptable salts thereof.