Loading patent…
AssigneeSynthelabo
InventorsMireille Sevrin, Benoit Marabout, Jacques Froissant, Catherine Guinot
Estimating the term…
A compound of formula (I) ##STR1## in which X represents a hydrogen atom, a halogen atom, a trifluoromethyl group, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group in which case two such alkoxy groups X can be present, Y represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group, R.sub.1 represents C.sub.1 -C.sub.4 alkyl group, and R represents a hydroxyl group, a methoxy group, an ethoxy group or a group of formula NR.sub.2 R.sub.3 in which R.sub.2 and R.sub.3 each independently represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, or a pharmaceutically acceptable addition salt thereof, processes for their preparation and their therapeutic application.
A compound of formula (I) ##STR5## in which X represents a hydrogen atom, a halogen atom, a trifluoromethyl group, a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group in which case two such alkoxy groups X can be present,
A compound of formula (I) selected from the group consisting of 2-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanoic acid, methyl 2-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propionate, ethyl 2-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanoate, N,2-dimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide, N,2-dimethyl-5-methoxy-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamid e, N,2,6-trimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide, 6-chloro-N,2-dimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide , 6-methoxy-N,2-dimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanami de, N,2,7-trimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide, 7-chloro-N,2-dimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide , N-butyl-7-chloro-2-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propan amide, 7-methoxy-N,2-dimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamid e, N,2-dimethyl-1-oxo-3-phenyl-7-trifluoromethyl-1,2-dihydroisoquinoline-4-pr opanamide, 8-methoxy-N,2-dimethyl-8-methoxy-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4- propanamide, 6,7-dimethoxy-N,2-dimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propan amide, N,2-dimethyl-1-oxo-3-(3-methylphenyl)-1,2-dihydroisoquinoline-4-propanamid e, N,2-dimethyl-1-oxo-3-(3-methoxyphenyl)-1,2-dihydroisoquinoline-4-propanami de, N,2-dimethyl-1-oxo-3-(3-chlorophenyl)-1,2-dihydroisoquinoline-4-propanamid e, N,2-dimethyl-1-oxo-3-(4-fluorophenyl)-1,2-dihydroisoquinoline-4-propanamid e, N,2-dimethyl-1-oxo-3-(4-chlorophenyl)-1,2-dihydroisoquinoline-4-propanamid e, N,2,7-trimethyl-1-oxo-3-(3-chlorophenyl)-1,2-dihydroisoquinoline-4-propana mide, N,2,7-trimethyl-1-oxo-3-(3-fluorophenyl)-1,2-dihydroisoquinoline-4-propana mide, N,N,2-trimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide, 7-chloro-N,N-diethyl-2-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-pro panamide, 2-ethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanoic acid, 2-ethyl-N-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide, 2-ethyl-N,N-dimethyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide 2-propyl-N-methyl-1-oxo-3-phenyl-1,2-dihydroisoquinoline-4-propanamide and pharmaceutically acceptable addition salts thereof.
Dependencies are inferred from the claim text.