Use of 11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them
AssigneeSandoz Ltd.
InventorsMaximilian Grassberger, Josef Gottfried Meingassner, Anton Stutz, Peter Stutz
Life of this patent
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Abstract
The compounds of formula I, ##STR1## have been found to have excellent topical activity. They are thus indicated for use in the topical treatment of inflammatory and hyperpoliferative skin diseases and of cutaneous manifestations of immunologically-induced illnesses, such as psoriasis.
Claims18
A method of topically treating inflammatory or hyperproliferative skin diseases or cutaneous manifestations of immunologically-mediated illnesses, in a mammal in need of said treatment, which comprises administering topically to said mammal in an amount effective for the treatment of inflammatory or hyperproliferative skin diseases or cutaneous manifestations of immunologically mediated illnesses a compound of formula I ##STR4## wherein R.sup.1 is optionally protected hydroxy,
- R.sup.2 is hydrogen or optionally protected hydroxy,
- R.sup.3 is methyl, ethyl, propyl or allyl,
- n is 1 or 2 and
- the symbol of a line and dotted line is a single bond or a double bond,
- in free form or in pharmaceutically acceptable salt form.
A method of topically treating atopical dermatitis, contact dermatitis, eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eosinophilias, or Alopecia areata in a mammal in need of said treatment, which comprises administering topically to said mammal in an amount effective for the treatment of atopical dermatitis, contact dermatitis, eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolyeis bulloea, urticaria, angioedemaes, vasculitides, erythomas, cutaneous eosinophilias, or Alopecia areata a compound of formula I ##STR6## wherein R.sup.1 is optionally protected hydroxy,
- R.sup.2 is hydrogen or optionally protected hydroxy,
- R.sup.3 is methyl ethyl, propyl or allyl,
- n is 1 or 2 and
- the symbol of a line and dotted line is a single bond or a double bond,
- in free form or in pharmaceutically acceptable salt form.
A method of topically treating atopical dermatitis, contact dermatitis, eczematous dermatitises, or seborrhoeic dermatitis in a mammal in need of said treatment, which comprises administering topically to said mammal in an amount effective for the treatment of atopical dermatitis, contact dermatitis, eczematous dermatitises, or seborrhoeic dermatitis a compound of formula I ##STR8## wherein R.sup.1 is optionally protected hydroxy,
- R.sup.2 is hydrogen or optionally protected hydroxy,
- R.sup.3 is methyl, ethyl, propyl or allyl,
- n is 1 or 2 and
- the symbol of a line and dotted line is a single bond or a double bond,
- in free form or in pharmaceutically acceptable salt form.
Dependencies are inferred from the claim text.