Fibrinogen receptor antagonists

A fibrinogen receptor antagonist of the following formula ##STR63## and pharmaceutically acceptable salts thereof, where X is ##STR64## wherein R.sup.1 is selected from the group consisting of hydrogen, C.sub.1-10 alkyl, aryl C.sub.0-8 alkyl, oxo, thio, amino C.sub.0-8 alkyl, C.sub.1-3 acylamino C.sub.0-8 alkyl, C.sub.1-6 alkylamino C.sub.0-8 alkyl, C.sub.1-6 dialkylamino C.sub.0-8 alkyl, C.sub.1-4 alkoxy C.sub.0-6 alkyl, carboxy C.sub.0-6 alkyl, C.sub.1-3 alkoxycarbonyl C.sub.0-6 alkyl, C.sub.1-4 alkylthio C.sub.0-6 alkyl, aryl C.sub.0-4 thio C.sub.0-6 alkyl, carboxy C.sub.0-6 alkyloxy, and hydroxy C.sub.0-6 alkyl;

• Y and A are independently chosen from the group consisting of ##STR65## wherein R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen, C.sub.1-10 alkyl, aryl C.sub.0-8 alkyl, oxo, thio, amino C.sub.0-8 alkyl, C.sub.1-3 acylamino C.sub.0-8 alkyl, C.sub.1-6 alkylamine C.sub.0-8 alkyl, C.sub.1-6 dialkylamine C.sub.0-8 alkyl. C.sub.1-4 alkoxy C.sub.0-6 alkyl. carboxy C.sub.0-6 alkyl, C.sub.1-3 alkoxycarbonyl C.sub.0-6 alkyl, C.sub.1-4 alkylthio C.sub.0-6 alkyl. aryl C.sub.0-4 thio C.sub.0-6 alkyl, carboxy C.sub.0-6 alkyloxy, and hydroxy C.sub.0-6 alkyl, and
• where m and n are integers independently chosen from 0-6, wherein and Y is attached to a ring atom of the aromatic six-membered ring;
• B is chosen from the group consisting of:
• ##STR66## where p=0-2, and where R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are independently chosen from the group consisting of:
• hydrogen, fluorine, C.sub.1-8 alkyl, hydroxyl, C.sub.0-6 alkyl--CH=CH--C.sub.1-6 alkyl C.sub.0-6 alkyl--CH=CH.sub.2 C.sub.0-6 alkyl--CH=CH--C.sub.0-6 alkylaryl C.sub.0-6 alkyl--C.ident.C--C.sub.1-6 alkyl C.sub.0-6 alkyl.ident.C--CH C.sub.0-6 alkyl--C.ident.C--C.sub.0-6 alkylaryl hydroxy C.sub.1-6 alkyl, carboxy C.sub.0-6 alkyl, C.sub.1-6 alkyloxy, C.sub.3-8 cycloalkyl, aryl C.sub.1-6 alkyloxy, aryl C.sub.0-6 alkyl, C.sub.1-6 alkylcarbonyloxy, C.sub.0-6 alkylamino C.sub.0-6 alkyl, aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, C.sub.0-6 dialkylamino C.sub.0-6 alkyl, aryl C.sub.0-6 alkylcarbonyloxy, C.sub.1-8 alkylsulfonylamino C.sub.0-6 alkyl, C.sub.1-6 alkylaminocarbonyloxy, aryl C.sub.0-6 alkylaminocarbonyloxy, aryl C.sub.0-8 alkylsulfonylamino C.sub.0-6 alkyl, C.sub.1-8 alkyloxycarbonylamino C.sub.0-8 alkyl, aryl C.sub.0-8 alkyloxycarbonylamino C.sub.0-8 alkyl, C.sub.1-8 alkylcarbonylamino C.sub.0-6 alkyl, aryl C.sub.0-6 alkylcarbonylamino C.sub.0-6 alkyl, C.sub.0-8 alkylaminocarbonylamino C.sub.0-6 alkyl, aryl C.sub.0-8 alkylaminocarbonylamino C.sub.0-6 alkyl, C.sub.0-8 alkylaminosulfonylamino C.sub.0-6 alkyl, aryl C.sub.0-8 alkylaminosulfonylamino C.sub.0-6 alkyl, C.sub.1-6 alkylsulfonyl C.sub.0-6 alkyl, aryl C.sub.0-6 alkylsulfonyl C.sub.0-6 alkyl, C.sub.1-6 alkylcarbonyl C.sub.0-6 alkyl, aryl C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, C.sub.1-6 alkylthiocarbonylamino C.sub.0-6 alkyl, aryl C.sub.0-6 alkylthiocarbonylamino C.sub.0-6 alkyl, C.sub.0-8 alkylaminocarbonyl C.sub.0-6 alkyl, and aryl C.sub.0-8 alkylaminocarbonyl C.sub.0-6 alkyl, unsubstituted or substituted with one or more substituents selected from R.sup.1, and ##STR67## where AA is an L- or D-amino acid, or its corresponding ester, connected through an amide linkage;
• R.sup.10 is chosen from the group consisting of:
• hydroxy, C.sub.1-8 alkyloxy, aryl C.sub.0-6 alkyloxy, C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyloxy, aryl C.sub.1-8 alkylcarbonyloxy C.sub.1-4 alkyloxy, C.sub.1-8 alkylaminocarbonyt C.sub.1-4 alkyloxy, C.sub.1-8 dialkylaminocarbonyl C.sub.1-4 alkyloxy, and an L- or D- amino acid joined by an amide linkage, wherein the carboxylic acid moiety of said amino acid is as the free acid or is esterified by C.sub.1-6 alkyl.