Carbacephalosporin compound, their preparation and use
AssigneePfizer Inc.
InventorsRichard Leonard Elliott, Neville Hubert Nicholson, Andrew Kenneth Takle
Life of this patent
Estimating the term…
Abstract
Carbacephalosporin compounds of formula (I), ##STR1## salts thereof, processes for their synthesis and uses thereof, wherein: R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is an acyl group; CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 represent hydrogen or a substituent; R.sup.4 and R.sup.7 may be replaced by a chemical bond between the two carbon atoms shown; R.sup.5 and R.sup.6 may be linked together into a cyclic system. The compounds (I) have antibacterial properties.
Claims16
A carbacephalosporin compound of formula (I) or a salt thereof:
- ##STR31## wherein R.sup.1 is hydrogen, methoxy or formamido;
- R.sup.2 is an acyl group;
- CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a readily removable carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group;
- R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently represent hydrogen or a substituent;
- wherein R.sup.4 and R.sup.7 optionally are absent and replaced by a chemical bond between the two carbon atoms shown;
- and wherein R.sup.5 and R.sup.6 optionally are linked together into a cyclic system of formula:
- ##STR32## wherein X represents --O-- or --NR.sup.8 --, wherein each R.sup.8 is the same or different and independently represents hydrogen or a substituent, or two groups R.sup.8 may be linked into a ring system, or any two adjacent --CR.sup.8.sub.2 -- units is replaced by a --CR.sup.8 .dbd.CR.sup.8 -- unit, and wherein n is an integer 1 to 7, m is O, 1, 2 or 3.
A pharmaceutical composition which comprises a compound of formula (Ia) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.