Platelet membrane glycoprotein F11 and polypeptide fragments thereof
AssigneeThe Research Foundation of State University of New York
InventorsElizabeth H. Kornecki, Yigal H. Ehrlich
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Abstract
The subject invention provides a platelet membrane glycoprotein, designated F11, which serves as a receptor for the monoclonal antibody M.Ab.F11. The purified platelet membrane glycoprotein has a deglycosylated molecular weight of about 29 kD. A partial sequence for the glycoprotein is also provided, as well as expression vectors and systems for producing the glycoprotein or fragments thereof.
Claims15
A purified platelet membrane glycoprotein designated F11.
A purified platelet membrane glycoprotein designated F11 having an amino acid sequence which contains amino acid sequences:
- ______________________________________ SEQ ID NO:8:
- Ser Val Thr Val His Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn Asn Pro Val Lys Leu Ser Cys Ala Tyr Gly Met Phe Gln Xaa Pro Xaa Ser Gly;
- SEQ ID NO:9:
- Phe Asp Lys Asp Xaa Thr Ile Tyr Leu Asn Xaa Tyr;
- SEQ ID NO:3:
- Lys Phe Lye Leu Ile Val Leu Val;
- SEQ ID NO;10:
- Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe Lys Ser Val Thr Arg Glu;
- SEQ ID NO:11:
- Trp Lys Phe Asp Gln Gly Asp Thr Thr Arg Leu Val Glu Tyr Asn Asn Lye Ile Thr Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe Lys Ser Val Thr Arg Glu Asp Xaa Gly Gln Tyr Leu Asp Met Asp;
- SEQ ID NO:12:
- Val Thr Phe Leu Pro Thr Gly Ile Thr Phe Lys;
- and SEQ ID NO:13:
- Leu Thr Asp Xaa Gly Gln, ______________________________________
- wherein Xaa at amino acid residue 43 of SEQ ID NO:11 is selected from the group consisting of a Cys and a glycosylated residue.
A purified platelet membrane glycoprotein designated F11 having an amino sequence which contains:
- ______________________________________ SEQ ID NO:8:
- ______________________________________ Ser Val Thr Val His Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn Asn Pro Val Lys Leu Ser Cys Ala Tyr Gly Met Phe Gln Xaa Pro Xaa Ser Gly. ______________________________________
A purified platelet membrane glycoprotein designated F11 having an amino acid sequence which contains:
- SEQ ID NO:9:
- Phe Asp Lys Asp Xaa Thr Ile Tyr Leu Asn Xaa Tyr.
A purified platelet membrane glycoprotein designated F11 having an amino acid sequence which contains:
- SEQ ID NO:3:
- Lys Phe Lys Leu Ile Val Leu Val.
A purified platelet membrane glycoprotein designated F11 having an amino acid sequence which contains:
- ______________________________________ SEQ ID NO:10:
- ______________________________________ Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe Lys Ser Val Thr Arg Glu. ______________________________________
A purified platelet membrane glycoprotein designated F11 having an amino acid sequence which contains:
- ______________________________________ SEQ ID NO:11:
- ______________________________________ Trp Lys Phe Asp Gln Gly Asp Thr Thr Arg Leu Val Glu Tyr Asn Asn Lys Ile Thr Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe Lye Ser Val Thr Arg Glu Asp Xaa Gly Gln Tyr Leu Asp Met Asp ______________________________________
- wherein Xaa at amino acid residue 43 of SEQ ID NO:11 is selected from the group consisting of Cys and a glycosylated residue.
A purified platelet membrane glycoprotein designated F11 having an amino acid sequence which contains:
- SEQ ID NO:12:
- Val Thr Phe Leu Pro Thr Gly Ile Thr Phe Lys.
A purified platelet membrane glycoprotein designated F11 having an amino acid sequence which contains:
- SEQ ID NO:13:
- Leu Thr Asp Xaa Gly Gln.
Dependencies are inferred from the claim text.