Pharmaceutical formulations
AssigneeSkua Investments Limited
InventorsYoung W. Cho, Michael John Flynn, Thomas Smith Shepherd
Life of this patent
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Abstract
A Pharmaceutical formulation comprises a biologically active material such as insulin, erythropoietin, calcitonin and growth hormone, and, associated with it, a phospholipid for forming a material which participates in the alpha-glycerol or other pathways for the formation of lecithins which are found in the intestinal epithelial cell. Biologically active protein orally administered in such a formulation are bioavailable and bioactive.
Claims46
A water-in-oil pharmaceutical formulation for oral or rectal administration comprising a hydrophilic phase dispersed in a lipophilic phase to form an emulsion,
- wherein said hydrophilic phase comprises (a) water, (b) a biologically active material and (c) in association with the biologically active material, lecithin or a lecithin precursor,
- wherein said lipophilic phase comprises (a) one or more oils, (b) a phospholipid and (c) a lipophilic surfactant,
- and wherein an emulsion is formed from said hydrophilic phase dispersed in said lipophilic phase.
A water-in-oil pharmaceutical formulation for oral or rectal administration comprising a hydrophilic phase dispersed in a lipophilic phase to form an emulsion,
- wherein said hydrophilic phase comprises (a) water, (b) a biologically active material and (c) in association with the biologically active material lecithin or a lecithin precursor,
- wherein said lipophilic phase comprises (a) materials that can be used to form a chylomicron matrix, (b) a phospholipid and (c) a lipophilic surfactant,
- and wherein an emulsion is formed from said hydrophilic phase dispersed in said lipophilic phase.
A water-in-oil pharmaceutical formulation for oral or rectal administration comprising a hydrophilic phase dispersed in a lipophilic phase to form an emulsion,
- wherein said hydrophilic phase comprises (a) water, (b) a biologically active material and (c) in association with the biologically active material, lecithin or a lecithin precursor comprising a phospholipid,
- wherein said lipophilic phase comprises (a) one or more oils, (b) a phospholipid and (c) a lipophilic surfactant,
- and wherein an emulsion is formed from said hydrophilic phase dispersed in said lipophilic phase.
A water-in-oil pharmaceutical formulation for oral or rectal administration comprising a hydrophilic phase dispersed in a lipophilic phase to form an emulsion,
- wherein said hydrophilic phase comprises (a) water, (b) a biologically active material and (c) in association with the biologically active material, a phospholipid, wherein said phospholipid has the general formula:
- ##STR4## and wherein each of R1 and R2 independently represents an acyl group and X represents a hydrogen atom or a phospholipid headgroup,
- wherein said lipophilic phase comprises (a) one or more oils, (b) a phospholipid and (c) a lipophilic surfactant,
- and wherein an emulsion is formed from said hydrophilic phase dispersed in said lipophilic phase.
Dependencies are inferred from the claim text.