Antisense oligonucleotide inhibition of papillomavirus transformed cells
AssigneeIsis Pharmaceuticals, Inc.
InventorsStanley T. Crooke, Christopher K. Mirabelli, David J. Ecker, Lex M. Cowsert
Life of this patent
Estimating the term…
Abstract
Antisense oligonucleotides are taught which hybridize to human papilloma virus transcripts. These oligonucleotides when added to tissue culture cells transformed with human papilloma virus inhibit growth of the transformed cell.
Claims3
A method of inhibiting the growth of human papillomavirus transformed cancer cells in vitro comprising introducing an antisense oligonucleotide having SEQ ID NO:
- 8 into said cancer cells in an amount sufficient to inhibit cell growth.
A method of inhibiting the growth of human papillomavirus transformed cancer cells in vitro comprising introducing an antisense oligonucleotide having SEQ ID NO:
- 9 into said cancer cells in an amount sufficient to inhibit cell growth.
A method of inhibiting the growth of human papillomavirus transformed cancer cells in vitro comprising introducing an antisense oligonucleotide having SEQ ID NO:
- 8 and SEQ ID NO:
- 9 into said cancer cells in an amount sufficient to inhibit cell growth.
Dependencies are inferred from the claim text.