Antibodies to plasmodium falciparum
AssigneeBecton, Dickinson and Company
InventorsS. Melissa Maret, Hans H. Feindt, Gerald DeWayne Hahn, Keith Uithoven
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Abstract
Antibodies which recognize and bind to histidine rich protein II of Plasmodium falciparum. These antibodies exhibit improved specificity and affinity for the antigen which provides enhanced sensitivity in immunoassays. Peptides useful for generation of the antibodies are also provided.
Claims10
A method for detecting HRP-II of Plasmodium falciparum comprising the steps of:
- a) contacting a sample with a monoclonal antibody produced by a hybridoma having ATCC Accession No. HB11111 or Accession No. HB11112;
- b) allowing the antibody to bind to the HRP-II to form an antibody/HRP-II complex, and;
- c) detecting the HRP-II by means of a detectable label included in the complex.
An immunoassay device comprising a microporous absorbent material in fluid communication with a second absorbent material, the microporous absorbent material having immobilized thereon a monoclonal antibody produced by a hybridoma having ATCC Accession No. HB11111 or Accession No. HB11112.
Dependencies are inferred from the claim text.