Matrix for sustained-release preparation
AssigneesTakeda Chemical Industries, Ltd., Wako Purechemical Industries, Ltd.
InventorsYasutaka Igari, Akira Saikawa, Kayoko Okamoto, Shigeru Kamei, Masahisa Oka, Atsunori Sano
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Abstract
The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid. The matrix is stable to light, heat, moisture, coloring etc., and is of low toxicity. The sustained-release preparation produced by using the ester of the present invention offers stable drug release over an extended period of time, ensuring sustained stable effect. Furthermore, the sustained-release preparation does not show excess drug release just after administration.
Claims10
A matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an .alpha.-hydroxymonocarboxylic acid, the polyester having a weight-average molecular weight of about 1,500 to about 50,000.
Dependencies are inferred from the claim text.