Stabilized tablet formulation
AssigneeSmithKline Beecham Corporation
InventorsPatrick Gerard Faulkner, Mark Warren Fisher, Joseph Peter Sauer, Carlos Roberto Hernandez
Life of this patent
Estimating the term…
Abstract
Invented are stabilized tablet formulations of substituted 3,5-diene steroidal compounds. Also invented are methods of preparing stabilized tablet formulations of substituted 3,5-diene steroidal compounds.
Claims2
A method of preparing stabilized tablet formulations of substituted 3,5-diene steroidal compounds wherein the improvement comprises, the process of reducing the significant increase in the rate of formation of degradation products formed from substituted 3,5-diene steroidal compounds whether compressed into tablets by wet granulation or by direct compression, with commonly used pharmaceutical excipients which consists essentially of the step of directly compressing said substituted 3,5-diene steroidal compound admixed with
- (A) from about 0.05% to about 2% by weight of butylated hydroxyonisol or butylated hydroxytoluene, as antioxidant, and
- (B) from about 1% to about 3% by weight of stearic acid or palmitic acid, as stabilizing tablet lubricant.
Dependencies are inferred from the claim text.