US 5,665,388 AGranted

Method for preparation of an alkaline and aspirin combination compound

AssigneeHealth Corporation

InventorHoward P. Phykitt

Life of this patent

Estimating the term…

Loading patent…

Abstract

A method of manufacturing a stabilized, essentially sodium free, granular aspirin compound mixed with a granular potassium bicarbonate compound comprising the steps of determining a desirable dose size of such aspirin compound which is to be packaged. Weighing out an amount of granular aspirin based on the dose size determined. Placing an amount of such granular potassium bicarbonate compound into a container which is uniformly distributed over a bottom surface of such container to a predetermined depth. Placing such container into a heat treating apparatus. Heat treating the granular potassium bicarbonate compound at a temperature which is at least sufficient to convert an outer surface layer of such granular potassium bicarbonate compound to potassium carbonate and for a time which is at least sufficient to ensure that essentially all of such outer surface layer of the granular potassium bicarbonate compound is converted to such potassium carbonate. Weighing out an amount of such heat treated granular potassium bicarbonate compound based on the dose size determined. Placing the granular aspirin into a package and, thereafter, placing such heat treated granular potassium bicarbonate compound into such package thereby forming the stabilized, essentially sodium free, granular aspirin compound mixed with a granular potassium bicarbonate compound.

A method of manufacturing a stabilized, essentially sodium free, granular aspirin compound mixed with a granular potassium bicarbonate compound, said method comprising the steps of:

(a) determining a desirable dose size of said stabilized, essentially sodium free, granular aspirin compound mixed with said granular potassium bicarbonate compound which is to be packaged;
(b) weighing out a predetermined amount of granular aspirin, having a predetermined particle size, based on said dose size determined in step (a);
(c) placing a predetermined amount of said granular potassium bicarbonate compound into a container, said potassium bicarbonate compound being substantially uniformly distributed over a bottom surface of said container to a predetermined depth;
(d) placing said container, containing said granular potassium bicarbonate compound therein, into a heat treating apparatus;
(e) heat treating said predetermined amount of said granular potassium bicarbonate compound at a predetermined temperature which is at least sufficient to convert an outer surface layer of said granular potassium bicarbonate compound to potassium carbonate and for a predetermined time which is at least sufficient to ensure that essentially all of said outer surface layer of said granular potassium bicarbonate compound is converted to said potassium carbonate;
(f) weighing out a predetermined amount of said granular potassium bicarbonate compound, after completion of said heat treating in step (e), based on said predetermined dose size determined in step (a);
(g) placing said predetermined amount of said granular aspirin, weighed out in step (b), into a package;
and
(h) placing said predetermined amount of said granular potassium bicarbonate compound, weighed out in step (f), into said package thereby forming said stabilized, essentially sodium free, granular aspirin compound mixed with said granular potassium bicarbonate compound.

6 more elements

Abstract

Claims20