Methods and compositions for primary and secondary prevention of autoimmune diabetes
AssigneeK.U. Leuven Research & Development
InventorsChantal Mathieu, Mark Waer, Roger Bouillon
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Abstract
A method for modulating the immune system by administering one or more vitamin D (analogues) to a subject in need of immune therapy, which method may (but need not) include simultaneous treatment with a second immune system modulating active agent. Preferably, the treatment method is used to induce primary or secondary prevention of type I diabetes in a subject susceptible to type I diabetes. Administration of the vitamin D (analogues) is enteral or parenteral.
Claims19
A method for modulating the immune system of a subject comprising administrating an amount in a range of 0.1 ug to 1 mg per kilogram body-weight of said subject of a first compound based on the formula ##STR4## wherin x is H.sub.2 or H(OH);
- Y is H(OH) or H(F);
- Z is H.sub.2 or H (alkyl) (C.sub.1 -C.sub.4);
- W is H.sub.2,.dbd.CH.sub.2 or H(CH.sub.3) and R is ##STR5## wherein one or more carbon atoms may be replaced by O or S and wherein n<3, or alkyl-, aryl-, alkenyl-, alkynyl-, fluoro-, thio-, cycloalkyl-, epoxy-, hydroxyl- or keto-containing derivatives thereof;
- and
- wherein said amount is effective to modulate the immune system in an animal or patient to which said amount is administered.
A pharmaceutical composition in unit dosage form effective to modulate the immune system, comprising at least one pharmaceutically acceptable excipient and an amount of a first compound based on the formula ##STR6## wherein x if H.sub.2 or H(OH);
- Y is H(OH) or H(F);
- Z is H.sub.2 or H (alkyl) (C.sub.1 -C.sub.4);
- W is H.sub.2,.dbd.CH.sub.2 or H(CH.sub.3) and R is ##STR7## wherein one or more carbon atoms may be replaced by O or S and wherein n<3 or alkyl-, aryl-, alkenyl-, alkynyl-, fluoro-, thio-, cycloalkyl-, epoxy-, hydroxyl- or keto-containing derivatives thereof;
- and
- wherein said amount is effective to modulate the immune system in an animal or patient to which said amount is administered.
Dependencies are inferred from the claim text.