Oily capsules of ketoprofen
AssigneeRhone-Poulenc Rorer S.A.
InventorsFrederic Courteille, Michel Veillard
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Abstract
Stable, pharmaceutical ketoprofen salts for oral administration are provided in oily solutions to avoid direct contact of acid forms of ketoprofen with the gastric or duodenal mucus membranes. Sodium, arginine, lysine and/or N-methylglucamine salts of ketoprofen are disclosed in solutions of polyoxyethyenatide vegetable oil, castor oil, esters of fatty acids and/or polyols. These oily solutions of ketoprofen may be administered orally in capsule form.
Claims11
A pharmaceutical composition comprising an oil solution of a ketoprofen salt, wherein oil is present in an amount greater than about 90% by weight of the solution and wherein ketoprofen salt is present in an amount of 1-8% by weight of the solution.
A pharmaceutical composition for oral administration comprising an oil solution of a ketoprofen salt and a ketroprofen salt solubility enhancer.
Dependencies are inferred from the claim text.