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US 5,665,381 AGranted
Inhibition of aggregation of drug containing particles
AssigneeNeXstar Pharmaceuticals, Inc.
InventorsCrispin G. S. Eley, Eric A. Forssen
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Abstract
A method and composition for the prevention of aggregation of liposomes which include a multivalent anion disposed on the outer surface thereof comprises the addition of a divalent cation to the external aqueous phase.
Claims7
A method for inhibiting aggregation of unilamellar liposomes containing an encapsulated drug and containing residual amounts of multivalent anions disposed on the outer surface of said liposomes, comprising
- (a) forming a dispersion of unilamellar liposomes containing an encapsulated drug wherein residual amounts of a multivalent anion are disposed on the outer surface of said liposomes;
- and
- (b) adding to said dispersion an effective amount to inhibit aggregation of a divalent cation selected from the group consisting of calcium and magnesium;
- wherein the liposomes have a mean diameter less than 200 nm and would otherwise aggregate in the absence of the divalent cation.
1 more element
Dependencies are inferred from the claim text.