Administration system for estradiol
AssigneeGiapharma SA
InventorJacques Gonella
Life of this patent
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Abstract
The adhesive plaster for the transdermal administration of estradiol or mixture estradiol/progestin is composed of an impermeable carrier film and of an adhesive composition. The latter represents a matrix or reservoir layer and is composed of a solvent-based polyacrylate or polyisobutylene adhesive which contains a saturated or unsaturated fatty acid with 6 to 18 C atoms as permeability enhancer, estradiol or mixture estradiol/progestin as active substance and optionally propylene glycol as solvent. The adhesive plaster is used for the systemic administration of hormones in hormone replacement therapy for a time of at least 3 days.
Claims8
An adhesive plaster for the transdermal administration of estradiol, which is composed of an impermeable carrier film and of an adhesive composition coated thereon, wherein the adhesive composition, which represents a matrix or reservoir layer, is a solvent-based polyacrylate or polyisobutylene adhesive which contains lauric acid as permeability enhancer at a concentration of 1 to 25% and estradiol as an active substance at a concentration of 0.5 to 3%.
Dependencies are inferred from the claim text.