Medicines which contain derivatives of proline or hydroxyproline
OwnerWilhelm Hoerrmanninventor
Life of this patent
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Abstract
Pharmaceutical compositions which comprise, as an active substance, (N-alkyl) derivatives of proline or hydroxyproline. Such compositions are useful in the treatment of cancer.
Claims4
A method of treating carcinomas or tumors of neuroectodermal origin selected from a group consisting of astrocytomas, gliomas and melanomas in a human patient, comprising administration to said patient orally or intravenously, about 0.01 g/kg-0.1 g/kg daily, of at least one N-alkyl compound selected from the group consisting of N-methyl-hydroxy-proline, N-methyl-proline, N-ethyl-hydroxy-proline, N-ethyl-proline, N-propyl-hydroxy-proline, N-propyl-proline, N-butyl-hydroxy-proline, N-butyl-proline and pharmaceutically acceptable derivatives of said N-alkyl compounds.
A pharmaceutical composition for oral or intravenous administration for treating carcinomas or tumors of neuroectodermal origin selected from a group consisting of astrocytomas, gliomas and melanomas in human patients, in need thereof, said composition comprising at least one N-alkyl compound selected from the group consisting of N-methyl-hydroxyproline, N-methyl-proline, N-ethyl-hydroxyproline, N-ethyl-proline, N-propyl-hydroxyproline, N-propyl-proline, N-butyl-hydroxyproline, N-butyl-proline and pharmaceutically acceptable derivatives of said N-alkyl compounds, in a therapeutically effective amount, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.