Formulations containing coumarins and the use thereof in the pharmaceutical and cosmetic fields
AssigneeIndena S.p.A.
InventorsEzio Bombardelli, Aldo Cristoni, Paolo Morazzoni
Life of this patent
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Abstract
The present invention relates to the use of coumarins such as esculoside, esculetin, extracts containing them and mixtures thereof, in combination with dimeric and oligomeric proanthocyanidins, in topical formulations for the treatment of peripheral vasculopathies, including the complications of acute venous stasis, or of the unesthetisms related to capillary alterations, or to improve the cicatrization processes. These coumarins, alone or in combination with proanthocyanidins, are also useful in atopical dermatitis and in the treatment of the haematomas.
Claims23
A topical pharmaceutical or cosmetic composition for increasing blood capillary density comprising about 1 to 2.5% by weight of at least one coumarin and about 0.3 to 1.5% by weight of at least one proanthocyanidin.
A method for increasing blood capillary density in a subject, which comprises topically applying a composition comprising at least about 1% by weight of at least one coumarin and at least about 0.3% by weight of at least one proanthocyanidin upon the subject in areas where increased blood capillary density is desired.
A method of treatment for atopic dermatitis and hematomas, comprising topically applying a composition comprising at least about 1% by weight of at least one coumarin and at least about 0.3% by weight of at least one proanthocyanidin to increase skin blood capillary density.
A topical pharmaceutical or cosmetic composition for increasing blood capillary density consisting essentially of at least about 1% by weight of at least one coumarin and at least about 0.3% by weight of at least one proanthocyanidin.
Dependencies are inferred from the claim text.