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US 5,665,356 AGranted
Human anti-Rh (D) monoclonal antibodies
AssigneeNational Blood Authority
InventorsBenjamin Arthur De Burgh Bradley, Alan Doyle, Belinda Mary Kumpel
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AssigneeNational Blood Authority
InventorsBenjamin Arthur De Burgh Bradley, Alan Doyle, Belinda Mary Kumpel
Estimating the term…
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG1 proteins; (c) having kappa light chains; (d) being Glm(3) or Glm(1,17) allotype; (e) binding to D.sup.u cells by an indirect antiglobulin test; (f) binding to D.sup.IV, D.sup.V and D.sup.VII variant antigens; and (g) not binding to D.sup.VI or D.sup.B variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent hemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibodies of cell lines ECACC 87091605 and 87091604 deposited at the European Collection of Animal Cell Cultures, Public Health Laboratory Service Center for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4, OJG, England on Sep. 16, 1987.
A method of suppressing an immunogenic response, wherein said immunogenic response is an anti-D response, in an Rh(D) negative, Rh(D) variant, or Rh(D.sup.u) human subject, following exposure of said subject to Rh(D) positive red blood cells by transfusion or pregnancy, comprising administering to said subject a human monoclonal antibody having the following characteristics:
A method of suppressing an immunogenic response, wherein said immunogenic response is an anti-D response, in an Rh(D) negative, Rh(D) variant, or Rh(D.sup.u) human subject, following exposure of said subject to Rh(D) positive red blood cells by transfusion or pregnancy, comprising administering to said subject a human monoclonal antibody having the following characteristics:
A method of passive immunization to prevent haemolytic disease of the newborn, comprising administering to an Rh(D) negative, Rh(D) variant, or Rh(D.sup.u) human female a human monoclonal antibody having the following characteristics:
A method of passive immunization to prevent haemolytic disease of the newborn, comprising administering to an Rh(D) negative, Rh(D) variant, or Rh(D.sup.u) human female a human monoclonal antibody having the following characteristics:
Dependencies are inferred from the claim text.