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US 5,665,350 AGranted
Cell cycle dependent transplantation and ex vivo gene therapy
AssigneeUniversity of Massachusetts Medical Center
InventorPeter J. Quesenberry
Life of this patent
Estimating the term…
Abstract
Methods for the enhancement of bone marrow stem cell engraftment are provided for use in transplantation therapy and ex vivo gene therapy of a mammal. The methods involve the transplantation of quiescent stem cells for transplantation therapy and quiescent transfected stem cells for ex vivo gene therapy.
Claims6
A method of introducing cells into a host mammal, said method comprising the steps of:
- a) providing a population of pluripotent hematopoietic stem cells;
- b) expanding said population of stem cells to yield a population of expanded stem cells;
- c) treating said population of expanded stem cells to induce said population of expanded stem cells to become quiescent stem cells;
- and
- d) introducing said quiescent stem cells into said host mammal.
2 more elements
A method of introducing transfected cells into a host mammal, said method comprising the steps of:
- a) providing a population of transfected pluripotent hematopoietic stem cells;
- b) inducing said population of transfected stem cells to become quiescent transfected stem cells;
- and
- c) introducing said quiescent transfected stem cells into said host mammal.
1 more element
Dependencies are inferred from the claim text.