IL-12 inhibition of B1 cell activity
AssigneesGenetics Institute, Inc., Medical College of Ohio
InventorsDennis W. Metzger, Victor H. Van Cleave
Life of this patent
Estimating the term…
Abstract
The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the invention relates to a method of treating a B1 cell disorder in a host, comprising administering to the host an effective therapeutic amount of IL-12. The invention further encompasses a method of screening for substances (e.g., proteins, peptides, small molecules) which enhance or suppress the inhibition of B1 cell activity by IL-12. The invention also relates to a substance identified by the methods of screening for a substance which enhances or suppresses IL-12 inhibition of B1 cell activity.
Claims7
A method of suppressing B1 cell activity in a host, comprising administering to the host an effective amount of IL-12.
A method associated with treating B1 cell activity of a disease involving a B1 cell disorder in a host, comprising administering to the host an effective amount of IL-12.
A method of assessing the ability of a substance to suppress IL-12 inhibition of B1 cell activity, comprising the steps of:
- a) combining the substance with cultured B1 cells and IL-12, under conditions appropriate for IL-12 inhibition of B1 cell activity;
- and
- b) assessing whether inhibition of B1 cell activity results,
- wherein activation of B1 cell activity is an indication that the substance suppresses IL-12 inhibition of B1 cell activity.
A method of assessing the ability of a substance to enhance IL-12 inhibition of B1 cell activity, comprising the steps of:
- a) combining the substance with cultured B1 cells and IL-12, under conditions appropriate for inhibition of B1 cell activity;
- and
- b) assessing whether enhancement of B1 cell activity results,
- wherein an increase in the inhibition of B1 cell activity above that observed in the presence of IL-12 is an indication that the substance interferes with B1 cell activity.
Dependencies are inferred from the claim text.