Human interleukin-8 analogs
AssigneeResearch Corporation Technologies, Inc.
InventorsIan Clark-Lewis, Bernhard Moser
Life of this patent
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Abstract
The present invention provides human interleukin-8 (IL-8) analogs that are modified in the Glu4 Leu5 Arg6 region, and have a core structure corresponding to the IL-8 (7-51) sequence are provided. These neutrophil binding analogs display altered IL-8 activities that can be exploited for therapeutic and other purposes. Such antagonists include those in which, for example, the Leu5 and/or Arg6 residues are replaced, and in which the Glu4 and/or Leu5 residues are deleted. Also provided are biologically active human interleukin-8 (IL-8) analogs comprising a core sequence that includes IL-8 (1-51), IL-8 (3-51) or IL-8 (4-51). The invention also provides pharmaceutical compositions containing the aforementioned analogs.
Claims28
An interleukin-8 (IL-8) analog comprising an amino acid sequence substantially equivalent to the human IL-8 1-72 sequence, wherein the amino acid sequence of said analog begins at residue Leu5 and continuing C-terminally at least to residue 51 or begins at residue Glu4, wherein said Glu4 is substituted for an amino acid other than Glu.
A biologically active analog of human interleukin-8 (IL-8), the analog having amino acid sequence substantially equivalent to the IL-8 sequence beginning at residue 3 and continuing C-terminally to a residue between residues 50 and 70.
Dependencies are inferred from the claim text.