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AssigneeNitrosci Pharmaceuticals LLC
InventorsGerald M. Rosen, William R. Herzog, Jr., Sovitj Pou
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A surface of a foreign body exposed to the flowing blood of a living being which normally would promote the aggregation of platelets in that blood to form a coating firmly affixed to that surface and thus restrict the flow of blood past that surface or to form a blood clot detachable from that surface which when detached could trigger a stroke, heart attack or partial loss of lung function, such as plastic tubing, a balloon or the end of a catheter surgically inserted in a blood vessel or a stem implanted therein, e.g., in conjunction with percutaneous transluminal coronary angioplasty or the interior wall of a length of plastic tubing used to transport the blood of a patient, undergoing hypothermic surgery, inhibits such aggregation when that surface is coated with a physiologically acceptable polymer, such as polyvinyl alcohol or fibrinin, containing dissolved or dispersed therein a nitroso compound, such as 2-methyl-2-nitrosopropane, which decomposes at body temperature and in so doing releases a platelet aggregation-inhibiting amount of nitric oxide during the post-surgical period when the individual is a high risk candidate for post-surgical foreign body-mediated platelet aggregation on or at the situs of the foreign body.
A method for the prevention of the aggregation of platelets from blood flowing in a living being resulting from exposure of the blood to a foreign body, which comprises coating the surface of the foreign body which contacts the blood prior to contact therewith, with a physiologically acceptable polymer which is insoluble in the blood and which contains physically dissolved or dispersed therein an amount of an .alpha.-substituted nitroso compound which slowly thermally decomposes at body temperature over a prolonged period and in so doing releases an amount of nitric oxide from the coating at a rate effective to inhibit the platelet aggregation which would otherwise be promoted by the foreign body.
An intravascular device adapted for insertion into a blood vessel of a living being, whose exterior surface is coated with a coating of a physiologically acceptable polymer which is insoluble in blood and which contains physically dissolved or dispersed therein an amount of an .alpha.-substituted nitroso compound which slowly thermally decomposes at the body temperature of the living being over a prolonged period and in so doing releases nitric oxide the platelet aggregation which could otherwise occur when the stent is implanted in a blood vessel.
An aqueous liquid composition comprising (a) an aqueous vehicle;
Dependencies are inferred from the claim text.