Immune stimulation by phosphorothioate oligonucleotide analogs
AssigneeIsis Pharmaceuticals, Inc.
InventorsStephen L. Hutcherson, Josephine M. Glover
Life of this patent
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Abstract
Methods of stimulating a local immune response in selected cells or tissues employing immunopotentiating oligonucleotide analogs having at least one phosphorothioate internucleotide bond are provided. Methods of enhancing the efficacy of a therapeutic treatment by stimulating a local immune response in selected cells or tissues employing oligonucleotide analogs having at least one phosphorothioate bond are also provided. The oligonucleotide analogs may have antisense efficacy in addition to immunopotentiating activity. Methods of modulating cytokine release in skin cells and immunopotentiators which include oligonucleotide analogs having at least one phosphorothioate bond capable of eliciting a local inflammatory response are also provided.
Claims19
A method of stimulating a local immune response in selected cells or tissues, which comprises administering an effective amount of an oligonucleotide analog having at least one phosphorothioate bond to selected cells or tissues.
A method of enhancing the efficacy of a therapeutic treatment by stimulating a local immune response in selected cells or tissues by administering an effective amount of an oligonucleotide analog having at least one phosphorothioate bond to the cells or tissues.
A method of stimulating a local immune response in selected cells or tissues to enhance the antiinfective or anticancer effect of an antisense oligonucleotide analog which comprises administering an effective amount of an antisense oligonucleotide analog having at least one phosphorothioate bond to cells or tissues which are infected or cancerous.
Dependencies are inferred from the claim text.