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AssigneeHemasure, Inc.
InventorsCharles M. Zepp, Donald L. Heefner
Estimating the term…
Method for inactivating non-enveloped viruses using a viricide-potentiating agent. In a preferred embodiment, the method may be used to inactivate non-enveloped viruses present within a sample of whole blood or a blood product and comprises (a) adding to the blood sample a photoactivatable viricide, such as a psoralen, hypericin, methylene blue, toluidine blue or the like, which, when activated, is effective in inactivating enveloped viruses; (b) adding to the blood sample a viricide-potentiating chemical agent that increases the sensitivity of non-enveloped viruses to the activated viricide; and (c) activating the photoactivatable viricide. Preferably, the viricide-potentiating chemical agent includes a first moiety which possesses an affinity for a component of the non-enveloped virus and a second moiety which includes a lipid tail, the first and second moieties being structurally interrelated so that, when the first moiety becomes associated with a component of the non-enveloped virus, the second moiety penetrates or at least partially surrounds the viral capsid of the non-enveloped virus. Examples of the chemical agent include cationic lipopolyamines, such as dioctadecylamidoglycylspermine.
A method for inactivating a non-enveloped virus, the non-enveloped virus having a viral capsid, said method comprising the steps of:
A method of increasing the susceptibility of a non-enveloped virus to a photoactivatable viricide, the non-enveloped virus having a viral capsid, said method comprising the step of administering to the non-enveloped virus a viricide-potentiating chemical agent in a concentration that increases the efficacy of the photoactivatable viricide against the non-enveloped virus, said viricide-potentiating chemical agent being selected from the group consisting of cationic lipopolyamines, 2-methoxy-6-chloro-9-octadecylaminoacridine and the following compound;
A method for inactivating a non-enveloped virus in a sample, the non-enveloped virus having a viral capsid, the sample consisting essentially of at least one of blood plasma, red blood cells and platelets, said method comprising the steps of:
A method for inactivating a non-enveloped virus, the non-enveloped virus having a viral capsid, said method comprising the steps of:
Dependencies are inferred from the claim text.