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US 5,661,025 AGranted
Self-assembling polynucleotide delivery system comprising dendrimer polycations
OwnerFrancis C. Szoka, Jr., Jean Haenslerinventors
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Abstract
A self-assembling polynucleotide delivery system comprises a dendrimer polycation aiding in the delivery of the polynucleotide to a desired address, and optionally other agents such as DNA masking agents, cell recognition agents, charge-neutralization agents, membrane-permeabilization agents, and subcellular-localization agents.
Claims6
A method for introducing a polynucleotide into a eukaryotic cell in vitro comprising the step of contacting the cell with a composition for presenting a polynucleotide to a subcellular component of a eukaryotic cell, comprising
- a polynucleotide;
- and
- a dendrimer polycation non-covalently coupled to the polynucleotide.
Dependencies are inferred from the claim text.